6. Best Place to Tie One On: Portland, Maine

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The other Portland may have the microbrewery rep, but it distributes its beers to half the country. Many of the best brews in Portland, Maine, can only be quaffed here. Oxbow, a classic American farmhouse brewery, just opened a tasting room downtown where you can try local favorite Space Cowboy, a low-alcohol ale, and full-flavor European-style beers like the Continental. Then head to Novare Res, one of the country’s best beer bars, with 33 rotating taps, including roughly ten Maine brews. Or join Summer Feet Cycling, which offers two-and-a-half-hour tours along the Old Port area, with stops at distilleries and breweries like Rising Tide and Urban Farm Fermenting (from $59).